Abstract

Research Article

Awareness and Knowledge of Specialists/Trainers and General Dental Practitioners about Medical-Related Osteonecrosis of the Jaws

Abdulhamit Taha Koca, Mustafa Bayhan, Yunus Ayberk Demir and Ayse Zeynep Zengin*

Published: 13 November, 2024 | Volume 9 - Issue 1 | Pages: 023-031

Introduction: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first reported in 2003. In 2014, it was revealed that not only bisphosphonates but also other antiresorptive and antiangiogenic drugs can cause osteonecrosis (Medication-related osteonecrosis of the jaw: MRONJ). 
The aim of this study is to compare awareness and knowledge about BRONJ and MRONJ among specialists/trainers (ST), general dental practitioners (GDP); and dentists who graduated before and after the year 2014. 
Materials and methods: A survey regarding demographic information and knowledge about BRONJ and MRONJ was prepared and delivered to dentists via social media.
Results: A total of 422 dentists participated in our study. It was observed that the awareness and knowledge about BRONJ and MRONJ were statistically higher in ST and in dentists who graduated in 2014 or later. In addition, when their specialties were compared to each other, it was seen that the awareness and knowledge of Oral and Maxillofacial Radiologists (OMR) and Oral and Maxillofacial Surgeons (OMS) were higher than others.
Discussion: According to the results of this study, it was seen that the awareness and knowledge of the ST group were higher than GDP, maybe because they may encounter these cases more. In addition, dentists who graduated in 2014 or later had higher awareness, maybe because MRONJ was coined and entered the dentistry education curriculum in 2014. Awareness and knowledge of OMR and OMS were found higher may be because they encounter these patients more frequently. 
Planning educational strategies for all dentists, especially GDP and dentists who graduated before 2014 is very important for post-graduate dentistry education.

Read Full Article HTML DOI: 10.29328/journal.johcs.1001050 Cite this Article Read Full Article PDF

Keywords:

Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ); Medication-Related Osteonecrosis of the Jaw (MRONJ); Osteonecrosis; Awareness

References

  1. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–7. Available from: https://doi.org/10.1016/s0278-2391(03)00720-1
  2. Pazdur R. Postmarketing safety review: Bisphosphonates. Food and Drug Administration, Office of Drug Safety.
  3. Bisphosphonates and other drugs affecting bone metabolism. In: British National Formulary. 69th ed. 2014;513.
  4. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B; American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws—2009 update. J Oral Maxillofac Surg. 2009;67(5 Suppl):2-12. Available from: https://doi.org/10.1016/j.joms.2009.01.009
  5. Ruggiero SL, Dodson TB, Fantasia J; American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw—2014 update. J Oral Maxillofac Surg. 2014;72(10):1938-1956. Available from: https://doi.org/10.1016/j.joms.2014.04.031
  6. Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. J Oral Maxillofac Surg. 2022;80(5):920-943. Available from: https://doi.org/10.1016/j.joms.2022.02.008
  7. Al-Eid R, Alduwayan T, Bin Khuthaylah M, Al Shemali M. Dentists' knowledge about medication-related osteonecrosis of the jaw and its management. Heliyon. 2020;6(7). Available from: https://doi.org/10.1016/j.heliyon.2020.e04321
  8. Al-Samman AA, Al-Ani RS. A cross-sectional survey on medication-related osteonecrosis of the jaws' knowledge and awareness in a sample of dental society. J Cranio-Maxillofac Surg. 2019;47(6):926–931. Available from: https://doi.org/10.1016/j.jcms.2019.02.006
  9. Escovedo M, García-Consuegra L, Junquera S, Olay S, Ascani G, Junquera L. Medication-related osteonecrosis of the jaw: A survey of knowledge, attitudes, and practices among dentists in the principality of Asturias (Spain). J Stomatol Oral Maxillofac Surg. 2018;119(5):395-400. Available from: https://doi.org/10.1016/j.jormas.2018.04.008
  10. Levin CK, Baker J, Nolan P, Coffey A. A survey of medication-related osteonecrosis of the jaw reporting and risk assessment by oral and maxillofacial surgeons. J Oral Maxillofac Surg. 2020;78(10)-E91. Available from: https://www.joms.org/article/S0278-2391(20)30931-9/abstract
  11. Tanna N, Steel C, Stagnell S, Bailey E. Awareness of medication-related osteonecrosis of the jaws (MRONJ) amongst general dental practitioners. Br Dent J. 2017;222(2):121-125. Available from: https://doi.org/10.1038/sj.bdj.2017.79
  12. Aslan E, Sener E, Önem E, Mert A, Çankaya H. Postgraduate dental students’ knowledge levels toward medication-related osteonecrosis of the jaws. Clin Exp Health Sci. 2023;13:829-836. Available from: https://doi.org/10.33808/clinexphealthsci.1209004
  13. Patil V, Acharya S, Vineetha R, Nikhil K. Awareness about medication-related osteonecrosis of the jaw among dental professionals: A multicenter study. Oral Health Prev Dent. 2020;18:505-509. Available from: https://doi.org/10.3290/j.ohpd.a43361
  14. Acharya S, Patil V, Ravindranath V, Kudva A, Nikhil K. Medication-related osteonecrosis of the jaw: Knowledge and perceptions of medical professionals on the usage of bone modifying agents and dental referrals. J Med Life. 2022;15(3):368-373. Available from: https://doi.org/10.25122/jml-2021-0085
  15. Ekici Ö. Awareness of medication-related osteonecrosis of the jaw among dentists working at public oral and dental health care centers in Ankara, Turkey. Turkiye Klinikleri J Dental Sci. 2021;27(1):98-107. Available from: http://dx.doi.org/10.5336/dentalsci.2020-74342
  16. Landi L, Oteri G, Barbato L, Discepoli N, Carrassi AM, Rigoni M, et al. Anti-resorptive therapy and MRONJ: A survey of the Italian Society of Periodontology and Implantology. Oral Dis. 2024. Available from: https://doi.org/10.1186/s10195-023-00713-7
  17. Saad F, Brown JE, Van Poznak C, Ibrahim T, Stemmer SM, Stopeck AT, et al. Incidence, risk factors, and outcomes of osteonecrosis of the jaw: Integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol. 2012;23:1341. Available from: https://doi.org/10.1093/annonc/mdr435
  18. Yamazaki T, Yamori M, Ishizaki T, Asai K, Goto K, Takahashi K, et al. Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: A cohort study. Int J Oral Maxillofac Surg. 2012;41:1397. Available from: https://doi.org/10.1016/j.ijom.2012.06.020
  19. Vahtsevanos K, Kyrgidis A, Verrou E, Katodritou E, Triaridis S, Andreadis CG, et al. Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol. 2009;27:5356. Available from: https://doi.org/10.1200/jco.2009.21.9584
  20. Arnaud MP, Talibi S, Lejeune-Cairon S. Knowledge and attitudes of French dentists on bone resorption inhibitors (bisphosphonates and denosumab): A cross-sectional study. J Stomatol Oral Maxillofac Surg. 2022;123(2):163-170. Available from: https://doi.org/10.1016/j.jormas.2021.04.010
  21. Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti C, Hope S, Drudge-Coates L, et al. Medication-related osteonecrosis of the jaw: Definition and best practice for prevention, diagnosis, and treatment. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127:117-135. Available from: https://doi.org/10.1016/j.oooo.2018.09.008
  22. Hallmer F, Andersson G, Gotrick B, Warfvinge G, Anderud J, Bjørnland T. Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw—a 4-year prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126:477. Available from: https://doi.org/10.1016/j.oooo.2018.08.015
  23. Sturrock A, Preshaw PM, Hayes C, Wilkes S. Perceptions and attitudes of patients towards medication-related osteonecrosis of the jaw (MRONJ): A qualitative study in England. BMJ Open. 2019;9(3). Available from: https://doi.org/10.1136/bmjopen-2018-024376
  24. British Dental Association. The state of general dental practice in 2013. Accessed January 2017.
  25. Ekmekcioglu A, Akay G, Karadag O, Gungor K. The awareness and knowledge of dentists of medication-related osteonecrosis of the jaw. Clin Exp Health Sci. 2021;11:163-169. Available from: https://dergipark.org.tr/en/download/article-file/999751
  26. Alhussain A, Peel S, Dempster L, Clokie C, Azarpazhooh A. Knowledge, practices, and opinions of Ontario dentists when treating patients receiving bisphosphonates. J Oral Maxillofac Surg. 2015;73(6):1095-1105. Available from: https://doi.org/10.1016/j.joms.2014.12.040
  27. Hennedige AA, Jayasinghe J, Khajeh J, Macfarlane TV. Systematic review on the incidence of bisphosphonate-related osteonecrosis of the jaw in children diagnosed with osteogenesis imperfecta. J Oral Maxillofac Res. 2013;4. Available from: https://doi.org/10.5037/jomr.2013.4401
  28. Duarte NT, Rech BO, Martins IG, Franco JB, Ortega KL. Can children be affected by bisphosphonate-related osteonecrosis of the jaw? A systematic review. Int J Oral Maxillofac Surg. 2020;49:183. Available from: https://doi.org/10.1016/j.ijom.2019.08.004
  29. Yoo JY, Park YD, Kwon YD. Survey of Korean dentists on the awareness of bisphosphonate-related osteonecrosis of the jaws: A survey on the awareness of BRONJ. J Investig Clin Dent. 2010;1(2):90-95. Available from: https://doi.org/10.1111/j.2041-1626.2010.00024.x
  30. Sahin O. Medication-related osteonecrosis of the jaw: A survey of knowledge, practices, and opinions of dentists. Ann Med Res. 2020;27(9):2421-2427. Available from: https://annalsmedres.org/index.php/aomr/article/view/932
  31. Gaballah K, Hassan M. Knowledge and attitude of dentists on bisphosphonates use in the UAE: A descriptive cross-sectional study. Int Surg J. 2017;4(4):1398. Available from: https://doi.org/10.18203/2349-2902.isj20171150
  32. Deveci H, Ugar Cankal DA. Investigation of the approach of dentists in Ankara to patients who use drugs such as bisphosphonates, denosumab, and similars. ADO Klinik Bilimler Dergisi. 2021;10(2):99-105. Available from: https://dergipark.org.tr/tr/download/article-file/1601489

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?